Semaglutide is safe for most people, but there are important things to know before starting. The United States Food and Drug Administration (FDA) approved semaglutide under several brand names for use in weight loss and the treatment of type 2 diabetes.
Like any medication, semaglutide has potential side effects and may not be tolerated well by a small number of people. Therefore, it is extremely important to consult with and remain under the supervision of a doctor and medical team when you are on a semaglutide program.
If you are considering a semaglutide regimen, speak with our Las Vegas medical weight loss clinic. Our team of medical professionals can help you understand your options and choose a path to the future. Contact us today to schedule a free consultation.
What Is Semaglutide?
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It mimics the GLP-1 hormone, which naturally occurs in the gut after food consumption. It is typically administered via subcutaneous injection or tablet.
Semaglutide affects areas of the brain responsible for controlling appetite, which can lead to feelings of fullness, reduced hunger, and potentially fewer calories consumed. When combined with better eating habits and exercise, semaglutide is an effective weight-loss medication.
GLP-1 medications, such as semaglutide, stimulate insulin production, which helps lower blood sugar levels. They were originally developed to manage type 2 diabetes. Semaglutide may also reduce the risks of cancer and heart disease for overweight individuals.
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Is Semaglutide FDA Approved?
The FDA has approved semaglutide under two different brand names and for distinct uses.
- Ozempic: Semaglutide, sold under the brand name Ozempic, was approved on December 5, 2017, for the treatment of type 2 diabetes. Along with better eating habits and increased exercise, Ozempic can help manage blood sugar.
- Wegovy: On June 4, 2021, the FDA approved semaglutide for weight management under the brand name Wegovy. It’s prescribed for people with a body mass index (BMI) of 30 or higher or at least 27 with one or more weight-related conditions.
While FDA approval does not mean GLP-1 medications are right for you, it does offer peace of mind if you are concerned about the safety of semaglutide for weight loss.
What Are the Side Effects of Semaglutide?
While semaglutide is safe, you should know about the possible problems before starting. Like all medications, semaglutide may cause side effects in some users. These issues are typically mild and often disappear as your body adjusts to the medication.
Some of the common side effects associated with semaglutide include:
- Nausea
- Constipation
- Diarrhea
- Abdominal discomfort
- Fatigue
- Loss of appetite
- Headache
- Indigestion
- Bloating
If you experience these or any other issues while on a semaglutide regimen, it is important to consult with your doctor. In some cases, they may make recommendations or adjust dosages that can reduce discomfort.
Serious Side Effects
A very small number of patients may experience side effects or complications that indicate a major medical concern. This is yet another reason to always stay in contact with medical professionals when using semaglutide. These serious side effects include:
- Pancreatitis
- Kidney problems
- Vision problems
- Allergic reactions
While these problems are very rare, it is important to know them before starting with semaglutide.
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Is Compounded Semaglutide Safe?
Compounded semaglutide is generally not a safe alternative to Ozempic or Wegovy. A compounded medication is a drug created by a licensed pharmacist or other healthcare professional to meet the needs of specific patients.
While pharmacies that create compounded medications are regulated, the medications themselves are not FDA-approved and may contain inconsistencies in their formulas. This has the potential for significant problems with a popular treatment like semaglutide.
The FDA’s concerns with unapproved GLP-1 drugs used for weight loss include dosing issues and the potential for counterfeit drugs. They have noted over 455 reports of negative events with compounded semaglutide as of February 2025.
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What Is the Safest Way to Use Semaglutide?
Semaglutide is safe as long as you know a few things before starting. Some key points to remember are:
- Consult with a doctor and get a prescription
- Do not use compounded semaglutide
- Alert your doctor if you experience side effects
- Serious side effects are possible, though very rare
- Stay in touch with doctors or medical professionals throughout your program
Most importantly, remember that, while very effective, semaglutide is not a miracle drug. You still need to do your part by eating better and getting some exercise.
Is Semaglutide Safe for You?
Semaglutide is safe for most people, but know before starting that your decision to use semaglutide or any other drug is a personal one. Only through discussions with your doctor and supervision by medical professionals throughout your program will you know if it is right for you.
Semaglutide’s side effects are minimal or nonexistent for some people and intolerable for others. Sticking with your program and seeking advice from your doctor gives you a better chance of managing potential issues.
At TrimBody M.D., every new patient is seen and treated by our in-house medical professionals. We don’t sell drugs; we sell programs. Contact us today to schedule a free consultation and discuss your weight loss options.
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